Summer 2025 - X-Ray Crystallography Internship

Company: Disability Solutions
Location: Princeton
Posted on: November 3, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .Position SummaryThe Structural Biology team at BMS uses X-ray crystallography and Cryo-Electron Microscopy (Cryo-EM) to determine high-resolution 3D structures of biological macromolecules. Both techniques are vital for structure-based drug design, but Cryo-EM has notable advantages over X-ray crystallography. It can solve structures of larger proteins and protein complexes, and unlike X-ray crystallography, is less stringent regarding protein purity and quantity. Crystallization of protein is not required for Cryo-EM, which eliminates one big uncertainty. During this internship, our focus will be on Cryo-EM, specifically purifying proteins for this method and optimizing the sample preparation workflow.The project involves expressing the target proteins in bacterial and/or eukaryotic systems and purifying them using highly selective affinity chromatography. Following initial purification, the proteins will be characterized with available biophysical methods and prepared for Cryo-EM analysis, which will be carried out using on-site Titan Krios electron microscope. Data obtained on microscope will be analyzed with CryoSPARC software and used for structure determination.Key Responsibilities

• Protein expression in bacterial and/or mammalian cells
• Protein purification using affinity, size exclusion, ion exchange chromatography
• Protein characterization using biophysical methods
• Preparation of samples for cryo-electron microscope
• Cryo-electron microscope operation, sample screening, analysis and data collection
• 3-dimensional structure determination theoryQualifications & Experience
  • Completed at least two years of undergraduate coursework at a university
  • Strong analytical and organizational skills
  • Excellent communication, collaboration and learning skills
  • Preferred majors: Chemistry, Biochemistry, Biophysics, Biology
  • Basic understanding of protein biochemistry
  • Basic lab technique skills If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Lancaster , Summer 2025 - X-Ray Crystallography Internship, Other , Princeton, Pennsylvania